Endocrine Abstracts

Objective: To evaluate the presence of glucose metabolism abnormalities and their impact on IGF-1 levels in patients with acromegaly.Methods: Ninety-three acromegalic patients (52 male/41 female) were included in this study who were seperated into three groups as normal glucose tolerance (NGT), prediabetes and diabetes mellitus (DM). Insulin resistance (IR) was calculated with homeostasis model assessment (HOMA). HOMA-IR >2.5 or ≤2.5 were defin...

Objective: The aim of the study is to evaluate both the long-term consequences of exposure to dopamine agonists (CAB and BRC) at the beginning and during pregnancy, and the effects of pregnancy on remission.Methods: Thirty-seven prolactinoma patients who developed 58 pregnancies while receiving DAs treatment were included in this retrospective study. Age of gestation; both maximum residual tumor diameter and PRL levels before conception; the course of pr...

Graves’ disease (GD) is an autoimmune and polygenic disorder. The genetic loci conferring susceptibility need to be still defined. Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene has been reported to be associated with GD in various ethnic groups. The aim of the present study was to determine whether CTLA-4 gene was associated with GD in Turkish population. We evaluated the allele distribution of the following loci: CTLA-4 exon 1 (+49 A/G) and promoter (−318 C/T) reg...

LCH is a rare proliferative histiocytic disorder, and it can infiltrate virtually any site in the body. Diabetes incipidus (DI) is the most common abnormality when there is involvement of the hypothalamic-pituitary axis (HPA). We have evaluated the anterior pituitary function and their responses to treatment in 9 patients (5M/4F; range 19–60 years) with proven LCH and DI. Endocrine evaluations consisted of clinical history, basal (GH, IGF-1, fT4, TSH, PRL, cortisol, LH, F...

Cytokines play a crucial role in the pathogenesis of autoimmune thyroid disease, and recent studies have demonstrated an association between cytokine gene polymorphisms and Graves’ disease (GD) in different ethnic groups.The aim of the present study was to investigate the relationship of IL-6, IL-10, TNF-α, TGF-β, and INF-γ gene polymorphisms with the development of GD in Turkish population. A total of 224 subjects were included in the study comprising of 1...

Introduction: Pituitary adenomas (PAs) that occur in a familial setting account for no more than 5%, which can be part of familial tumor syndromes such as Multiple Endocrine Neoplasia type 1 (MEN1) and type 4 (MEN4), Carney Complex (CNC) or Familial Isolated Pituitary Adenoma (FIPA). The presence of two or more cases of PAs without MEN1 or CNC characteristics in the same family, enable FIPA diagnosis. Heterozygous germline inactivating mutations in the aryl hydrocarbon rec...

Purpose: Somatotrophinomas have been shown to demonstrate T2-weighted signal intensity (WSI) on MRI that is correlated with clinicopathological findings and response to treatment. Therefore, we aimed to investigate these correlations in functional pituitary adenomas, including prolactinoma and corticotrophinoma. Material and MethodsPatients with somatotrophinoma (n=87), prolactinoma (n=78) and corticotrophinoma (n=33) were invo...

Introduction: The aim of this study was to evaluate the worth of the salivary cortisol after overnight 1 mg dexamethasone suppression test (DST) in different patients.Materials and methods: The patient groups of the study consisted of 18 Cushing’s syndrome patients, 12 patients with non-functional adrenal incidentaloma, 37 patients with obesity, 16 patients with hirsutism and 26 healthy control patients. Salivary cortisol (SC) and plasma cortisol af...

Primary hyperparathyroidism (PHP) during pregnancy is a very rare event that increases maternal and fetal morbidity and mortality. Complications during pregnancy or neonatal period have included spontaneous abortion, stillbirth, neonatal death, neonatal tetany.Management of maternal PHP diagnosed during pregnancy should be based on the patients’ symptoms and severity of the disease. Hyperparathyroidism characterized by progressive symptoms should be...

Ectopic ACTH syndrome (EAS) occurs in around 10% of all cases with ACTH-dependent hypercortisolism. The mean age of clinical presentation varies from 45 to 50 years, and most of them caused by intrathoracic neoplasm, and recognition of the disorder may be delay. Subsequently, it may be difficult to locate the ACTH source and manage the patients’ hypercortisolism. We present our patients with EAS from 2000 to 2007. Four patients, aged 15–43 years, two females and two ...